Figure 5: B-mode and passive acoustic mapping (PAM) results for in vivo pressure ramp. (a-c) B-mode with PAM overlay showing peak source power for 1.2, 1.6 and 2.0 MPa peak negative focal pressures. The mouse body (left), tumour (centre) and nonmagnetic bar (right) are visible in the B-mode image. The rightmost area overlapping with the metal bar in (c) is an artefact caused by reflection against the metal surface which was only significant at this amplitude. (d) Maximum source power and (e) spectra for the 3 pressures. (f) Mean and standard deviation of source power at the 3 injection points (1, 4, 7 mins) vs. background cavitation 1 minute before each injection (0, 3, 6 mins).